Assay Detail
Functional
CHEMBL3375324
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LS174T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.16 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | — | 1 | 6.06 |
| CHEMBL213805 | — | — | 1 | 5.46 |
| CHEMBL209467 | — | — | 1 | 4.75 |
| CHEMBL213302 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL213805 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL209467 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL213302 | — | IC50 | = | 42000.0 | nM | 4.38 |