Assay Detail
Functional
CHEMBL3375333
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Growth inhibition of mouse BNL-SVA.8 cells after 48 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.86 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL213805 | — | — | 1 | 5.42 |
| CHEMBL209467 | — | — | 1 | 4.66 |
| CHEMBL213302 | — | — | 1 | 4.50 |
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL213805 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL209467 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL213302 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL258765 | FASCAPLYSIN CHLORIDE | IC50 | - | — | - |