Assay Detail
Binding
CHEMBL3375345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel 4-anilinoquinazoline derivatives as potent EGFR inhibitors both under normoxia and hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.90 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360608 | — | — | 1 | 9.59 |
| CHEMBL3360603 | — | — | 1 | 9.51 |
| CHEMBL3360606 | — | — | 1 | 9.49 |
| CHEMBL3360619 | — | — | 1 | 9.48 |
| CHEMBL3360618 | — | — | 1 | 9.43 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.35 |
| CHEMBL3360609 | — | — | 1 | 9.33 |
| CHEMBL3360617 | — | — | 1 | 9.31 |
| CHEMBL3360604 | — | — | 1 | 9.28 |
| CHEMBL3360611 | — | — | 1 | 9.27 |
| CHEMBL3360610 | — | — | 1 | 9.24 |
| CHEMBL3360607 | — | — | 1 | 9.19 |
| CHEMBL3360602 | — | — | 1 | 9.11 |
| CHEMBL3352899 | — | — | 1 | 9.11 |
| CHEMBL3360620 | — | — | 1 | 9.09 |
| CHEMBL3360605 | — | — | 1 | 8.84 |
| CHEMBL3360613 | — | — | 1 | 7.92 |
| CHEMBL3360614 | — | — | 1 | 7.78 |
| CHEMBL3360616 | — | — | 1 | 7.70 |
| CHEMBL3360612 | — | — | 1 | 7.52 |
| CHEMBL3360615 | — | — | 1 | 7.45 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | - |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360608 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL3360603 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL3360606 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL3360619 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL3360618 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL939 | GEFITINIB | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL3360609 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3360617 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL3360604 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL3360611 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL3360610 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3360607 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3360602 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL3352899 | — | IC50 | = | 0.78 | nM | 9.11 |
| CHEMBL3360620 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL3360605 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL3360613 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL3360614 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL3360616 | — | IC50 | = | 20.1 | nM | 7.70 |
| CHEMBL3360612 | — | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL3360615 | — | IC50 | = | 35.5 | nM | 7.45 |
| CHEMBL553 | ERLOTINIB | IC50 | - | — | - | |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | - | — | - |