Assay Detail
Functional
CHEMBL3375393
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Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.04 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.58 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.97 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL3353768 | — | — | 1 | 5.07 |
| CHEMBL3353783 | — | — | 1 | 5.04 |
| CHEMBL3353774 | — | — | 1 | 5.02 |
| CHEMBL3353778 | — | — | 1 | 4.79 |
| CHEMBL3353767 | — | — | 1 | 4.78 |
| CHEMBL3353764 | — | — | 1 | 4.69 |
| CHEMBL3353776 | — | — | 1 | 4.69 |
| CHEMBL3353765 | — | — | 1 | 4.63 |
| CHEMBL3353775 | — | — | 1 | 4.50 |
| CHEMBL3353770 | — | — | 1 | 4.46 |
| CHEMBL3353769 | — | — | 1 | 4.42 |
| CHEMBL3353763 | — | — | 1 | - |
| CHEMBL3353772 | — | — | 1 | - |
| CHEMBL3353773 | — | — | 1 | - |
| CHEMBL3353771 | — | — | 1 | - |
| CHEMBL3353777 | — | — | 1 | - |
| CHEMBL3353779 | — | — | 1 | - |
| CHEMBL3353780 | — | — | 1 | - |
| CHEMBL3353766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3353768 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3353783 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3353774 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL3353778 | — | IC50 | = | 16360.0 | nM | 4.79 |
| CHEMBL3353767 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL3353764 | — | IC50 | = | 20210.0 | nM | 4.69 |
| CHEMBL3353776 | — | IC50 | = | 20610.0 | nM | 4.69 |
| CHEMBL3353765 | — | IC50 | = | 23610.0 | nM | 4.63 |
| CHEMBL3353775 | — | IC50 | = | 31600.0 | nM | 4.50 |
| CHEMBL3353770 | — | IC50 | = | 34620.0 | nM | 4.46 |
| CHEMBL3353769 | — | IC50 | = | 37720.0 | nM | 4.42 |
| CHEMBL3353763 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353772 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353773 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353771 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353777 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353779 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353780 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3353766 | — | IC50 | > | 50000.0 | nM | - |