Assay Detail
Functional
CHEMBL3375436
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human XBP1 splicing in human HT1080-CMV-XBP1-Luciferase cells assessed as luciferase signal by Promega Bright-Glo luciferase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-1080 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.76 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356002 | — | — | 1 | 7.89 |
| CHEMBL3355998 | — | — | 1 | 7.51 |
| CHEMBL3355999 | — | — | 1 | 7.48 |
| CHEMBL3356001 | — | — | 1 | 7.48 |
| CHEMBL3356007 | — | — | 1 | 7.38 |
| CHEMBL3356003 | — | — | 1 | 7.29 |
| CHEMBL3356006 | — | — | 1 | 7.21 |
| CHEMBL3356009 | — | — | 1 | 7.00 |
| CHEMBL3356008 | — | — | 1 | 6.92 |
| CHEMBL3355993 | — | — | 1 | 6.70 |
| CHEMBL3355992 | — | — | 1 | 6.57 |
| CHEMBL3355996 | — | — | 1 | 6.51 |
| CHEMBL3356000 | — | — | 1 | 6.47 |
| CHEMBL3356005 | — | — | 1 | 6.36 |
| CHEMBL3356010 | — | — | 1 | 6.24 |
| CHEMBL3355997 | — | — | 1 | 6.24 |
| CHEMBL3356004 | — | — | 1 | 6.23 |
| CHEMBL3355995 | — | — | 1 | 6.06 |
| CHEMBL3355994 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356002 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3355998 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3355999 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3356001 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3356007 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3356003 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3356006 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3356009 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL3356008 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3355993 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3355992 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3355996 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3356000 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3356005 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3356010 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3355997 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3356004 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3355995 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3355994 | — | IC50 | = | 15000.0 | nM | 4.82 |