Assay Detail
Binding
CHEMBL3375438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human wild type JNK3 using biotinylated ATF2 substrate assessed as phosphorylation at thr53 on ATF2 by fluorescent plate reader
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.11 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356001 | — | — | 1 | 8.72 |
| CHEMBL3355999 | — | — | 1 | 8.72 |
| CHEMBL3355996 | — | — | 1 | 8.26 |
| CHEMBL3356003 | — | — | 1 | 8.15 |
| CHEMBL3356000 | — | — | 1 | 8.12 |
| CHEMBL3355995 | — | — | 1 | 7.92 |
| CHEMBL3355997 | — | — | 1 | 7.85 |
| CHEMBL3356002 | — | — | 1 | 7.70 |
| CHEMBL3355998 | — | — | 1 | 7.51 |
| CHEMBL3355994 | — | — | 1 | 7.50 |
| CHEMBL3355992 | — | — | 1 | 6.46 |
| CHEMBL3356006 | — | — | 1 | 6.40 |
| CHEMBL3356010 | — | — | 1 | 6.40 |
| CHEMBL3356008 | — | — | 1 | 6.27 |
| CHEMBL3355993 | — | — | 1 | 6.15 |
| CHEMBL3356005 | — | — | 1 | 5.92 |
| CHEMBL3356007 | — | — | 1 | 5.80 |
| CHEMBL3356004 | — | — | 1 | 5.66 |
| CHEMBL3356009 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356001 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3355999 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL3355996 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3356003 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3356000 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3355995 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3355997 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3356002 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3355998 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3355994 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3355992 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3356006 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3356010 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3356008 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3355993 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL3356005 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3356007 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3356004 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3356009 | — | IC50 | = | 2500.0 | nM | 5.60 |