Assay Detail
Functional
CHEMBL3375550
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Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.39 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 4.91 |
| CHEMBL3322149 | — | — | 1 | 4.69 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | — | 1 | 4.46 |
| CHEMBL3322147 | — | — | 1 | 4.39 |
| CHEMBL3322097 | — | — | 1 | 4.38 |
| CHEMBL3322143 | — | — | 1 | 4.38 |
| CHEMBL3322095 | — | — | 1 | 4.36 |
| CHEMBL3322100 | — | — | 1 | 4.35 |
| CHEMBL3322102 | — | — | 1 | 4.35 |
| CHEMBL3322151 | — | — | 1 | 4.35 |
| CHEMBL3322152 | — | — | 1 | 4.34 |
| CHEMBL3322144 | — | — | 1 | 4.33 |
| CHEMBL3322150 | — | — | 1 | 4.32 |
| CHEMBL3322099 | — | — | 1 | 4.30 |
| CHEMBL3322153 | — | — | 1 | 4.28 |
| CHEMBL3322154 | — | — | 1 | 4.26 |
| CHEMBL3322096 | — | — | 1 | 4.25 |
| CHEMBL3322103 | — | — | 1 | 4.25 |
| CHEMBL3322105 | — | — | 1 | - |
| CHEMBL3322148 | — | — | 1 | - |
| CHEMBL3322146 | — | — | 1 | - |
| CHEMBL3322145 | — | — | 1 | - |
| CHEMBL3322104 | — | — | 1 | - |
| CHEMBL3322101 | — | — | 1 | - |
| CHEMBL3322098 | — | — | 1 | - |
| CHEMBL3322094 | — | — | 1 | - |
| CHEMBL3322093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 12420.0 | nM | 4.91 |
| CHEMBL3322149 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL243263 | 6-HYDROXYCOUMARIN | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL3322147 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL3322097 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL3322143 | — | IC50 | = | 41600.0 | nM | 4.38 |
| CHEMBL3322095 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL3322100 | — | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL3322102 | — | IC50 | = | 44400.0 | nM | 4.35 |
| CHEMBL3322151 | — | IC50 | = | 44600.0 | nM | 4.35 |
| CHEMBL3322152 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3322144 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL3322150 | — | IC50 | = | 47800.0 | nM | 4.32 |
| CHEMBL3322099 | — | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL3322153 | — | IC50 | = | 52120.0 | nM | 4.28 |
| CHEMBL3322154 | — | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL3322096 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL3322103 | — | IC50 | = | 55800.0 | nM | 4.25 |
| CHEMBL3322105 | — | IC50 | - | — | - | |
| CHEMBL3322148 | — | IC50 | - | — | - | |
| CHEMBL3322146 | — | IC50 | - | — | - | |
| CHEMBL3322145 | — | IC50 | - | — | - | |
| CHEMBL3322104 | — | IC50 | - | — | - | |
| CHEMBL3322101 | — | IC50 | - | — | - | |
| CHEMBL3322098 | — | IC50 | - | — | - | |
| CHEMBL3322094 | — | IC50 | - | — | - | |
| CHEMBL3322093 | — | IC50 | - | — | - |