Assay Detail
Binding
CHEMBL3375810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Tyk2 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.92 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3352835 | — | — | 1 | 7.80 |
| CHEMBL3354186 | — | — | 1 | 7.44 |
| CHEMBL3354185 | — | — | 1 | 5.51 |
| CHEMBL3354190 | — | — | 1 | - |
| CHEMBL3354191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3352835 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3354186 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3354185 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL3354190 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3354191 | — | Ki | > | 1000.0 | nM | - |