Assay Detail
Binding
CHEMBL3375828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged sirtuin-2 (unknown origin) using KI179 as substrate after 1 hr by fluorescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.31 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2164016 | — | — | 1 | 5.82 |
| CHEMBL3354204 | — | — | 1 | 5.75 |
| CHEMBL3354206 | — | — | 1 | 5.70 |
| CHEMBL3354201 | — | — | 1 | 5.43 |
| CHEMBL2164014 | — | — | 1 | 5.37 |
| CHEMBL2164015 | — | — | 1 | 5.35 |
| CHEMBL2164005 | — | — | 1 | 5.17 |
| CHEMBL3354205 | — | — | 1 | 5.02 |
| CHEMBL3354214 | — | — | 1 | 4.91 |
| CHEMBL3354221 | — | — | 1 | 4.54 |
| CHEMBL3354199 | — | — | 1 | - |
| CHEMBL3354216 | — | — | 1 | - |
| CHEMBL3354202 | — | — | 1 | - |
| CHEMBL3354203 | — | — | 1 | - |
| CHEMBL3354207 | — | — | 1 | - |
| CHEMBL3354208 | — | — | 1 | - |
| CHEMBL3354209 | — | — | 1 | - |
| CHEMBL3354210 | — | — | 1 | - |
| CHEMBL3354211 | — | — | 1 | - |
| CHEMBL3354212 | — | — | 1 | - |
| CHEMBL3354198 | — | — | 1 | - |
| CHEMBL3354223 | — | — | 1 | - |
| CHEMBL3354222 | — | — | 1 | - |
| CHEMBL3354220 | — | — | 1 | - |
| CHEMBL3354219 | — | — | 1 | - |
| CHEMBL3354218 | — | — | 1 | - |
| CHEMBL3354217 | — | — | 1 | - |
| CHEMBL3354196 | — | — | 1 | - |
| CHEMBL3354200 | — | — | 1 | - |
| CHEMBL3354197 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2164016 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3354204 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3354206 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3354201 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2164014 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2164015 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2164005 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL3354205 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3354214 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3354221 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL3354216 | — | IC50 | - | — | - | |
| CHEMBL3354202 | — | IC50 | - | — | - | |
| CHEMBL3354203 | — | IC50 | - | — | - | |
| CHEMBL3354207 | — | IC50 | - | — | - | |
| CHEMBL3354208 | — | IC50 | - | — | - | |
| CHEMBL3354209 | — | IC50 | - | — | - | |
| CHEMBL3354210 | — | IC50 | - | — | - | |
| CHEMBL3354211 | — | IC50 | - | — | - | |
| CHEMBL3354212 | — | IC50 | - | — | - | |
| CHEMBL3354213 | — | IC50 | - | — | - | |
| CHEMBL3354215 | — | IC50 | - | — | - | |
| CHEMBL3354199 | — | IC50 | - | — | - | |
| CHEMBL3354198 | — | IC50 | - | — | - | |
| CHEMBL3354223 | — | IC50 | - | — | - | |
| CHEMBL3354222 | — | IC50 | - | — | - | |
| CHEMBL3354220 | — | IC50 | - | — | - | |
| CHEMBL3354219 | — | IC50 | - | — | - | |
| CHEMBL3354218 | — | IC50 | - | — | - | |
| CHEMBL3354217 | — | IC50 | - | — | - | |
| CHEMBL3354196 | — | IC50 | - | — | - | |
| CHEMBL3354200 | — | IC50 | - | — | - | |
| CHEMBL3354197 | — | IC50 | - | — | - |