Assay Detail
Binding
CHEMBL3376040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC3 using RHKK(Ac) as substrate by fluorimetric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.66 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3098602 | — | — | 1 | 8.70 |
| CHEMBL3353925 | — | — | 1 | 8.30 |
| CHEMBL3353927 | — | — | 1 | 7.96 |
| CHEMBL3098604 | — | — | 1 | 7.96 |
| CHEMBL3098691 | — | — | 1 | 7.21 |
| CHEMBL3098695 | — | — | 1 | 7.06 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3098602 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3353925 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3353927 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3098604 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3098691 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3098695 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 350.0 | nM | 6.46 |