Assay Detail
Functional
CHEMBL3376046
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Antiprotozoan activity against Trypanosoma brucei rhodesiense STIB 900 trypomastigotes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.63 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | 3.0 | 1 | 8.22 |
| CHEMBL3353928 | — | — | 1 | 5.62 |
| CHEMBL3353926 | — | — | 1 | 5.60 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.50 |
| CHEMBL3353925 | — | — | 1 | 5.49 |
| CHEMBL3098602 | — | — | 1 | 5.38 |
| CHEMBL3353927 | — | — | 1 | 5.32 |
| CHEMBL3098604 | — | — | 1 | 5.26 |
| CHEMBL3098695 | — | — | 1 | 5.22 |
| CHEMBL3098691 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166 | MELARSOPROL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3353928 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL3353926 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL3353925 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL3098602 | — | IC50 | = | 4155.0 | nM | 5.38 |
| CHEMBL3353927 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL3098604 | — | IC50 | = | 5515.0 | nM | 5.26 |
| CHEMBL3098695 | — | IC50 | = | 6045.0 | nM | 5.22 |
| CHEMBL3098691 | — | IC50 | = | 19950.0 | nM | 4.70 |