Assay Detail
Functional
CHEMBL3376105
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Vasodilative activity in isolated Sprague-Dawley rat mesenteric arterial ring assessed as reduction in KCl-induced contraction by wire myograph method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Mesenteric artery |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Discovery of novel 3-benzylquinazolin-4(3H)-ones as potent vasodilative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 4.97 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475534 | NITRENDIPINE | 3.0 | 1 | 8.40 |
| CHEMBL3357832 | — | — | 1 | 6.60 |
| CHEMBL3357830 | — | — | 1 | 6.40 |
| CHEMBL3357827 | — | — | 1 | 6.30 |
| CHEMBL3357840 | — | — | 1 | 6.20 |
| CHEMBL3357833 | — | — | 1 | 6.00 |
| CHEMBL3357834 | — | — | 1 | 5.50 |
| CHEMBL3357828 | — | — | 1 | 5.10 |
| CHEMBL3357837 | — | — | 1 | 5.10 |
| CHEMBL3357836 | — | — | 1 | 5.00 |
| CHEMBL3357841 | — | — | 1 | 4.90 |
| CHEMBL3357826 | — | — | 1 | 4.70 |
| CHEMBL3357839 | — | — | 1 | 4.70 |
| CHEMBL3357820 | — | — | 1 | 4.60 |
| CHEMBL3357821 | — | — | 1 | 4.60 |
| CHEMBL3357838 | — | — | 1 | 4.50 |
| CHEMBL3357831 | — | — | 1 | 4.50 |
| CHEMBL3357823 | — | — | 1 | 4.50 |
| CHEMBL3357822 | — | — | 1 | 4.40 |
| CHEMBL3357819 | — | — | 1 | 4.40 |
| CHEMBL3357815 | — | — | 1 | 4.30 |
| CHEMBL3357825 | — | — | 1 | 4.30 |
| CHEMBL3357817 | — | — | 1 | 4.30 |
| CHEMBL3357824 | — | — | 1 | 4.20 |
| CHEMBL3357816 | — | — | 1 | 4.20 |
| CHEMBL3357829 | — | — | 1 | 4.20 |
| CHEMBL3357818 | — | — | 1 | 4.10 |
| CHEMBL3357835 | — | — | 1 | 4.00 |
| CHEMBL3357814 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475534 | NITRENDIPINE | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3357832 | — | EC50 | = | 251.19 | nM | 6.60 |
| CHEMBL3357830 | — | EC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3357827 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3357840 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3357833 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3357834 | — | EC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL3357828 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3357837 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3357836 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3357841 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL3357826 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3357839 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL3357820 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL3357821 | — | EC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL3357838 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL3357831 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL3357823 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL3357822 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL3357819 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL3357815 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL3357825 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL3357817 | — | EC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL3357824 | — | EC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3357816 | — | EC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3357829 | — | EC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL3357818 | — | EC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL3357835 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3357814 | — | EC50 | = | 100000.0 | nM | 4.00 |