Assay Detail
Binding
CHEMBL3376290
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Inhibition of His-tagged Escherichia coli DXR pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL4091) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.56 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.50 |
| CHEMBL2316879 | — | — | 1 | 5.51 |
| CHEMBL3309759 | — | — | 1 | 5.50 |
| CHEMBL3309761 | — | — | 1 | 5.48 |
| CHEMBL3309760 | — | — | 1 | 5.44 |
| CHEMBL3309763 | — | — | 1 | 5.42 |
| CHEMBL3309758 | — | — | 1 | 5.39 |
| CHEMBL3309762 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2316879 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3309759 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3309761 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3309760 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3309763 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3309758 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3309762 | — | IC50 | = | 58000.0 | nM | 4.24 |