Assay Detail
Functional
CHEMBL3376507
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Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary mechanistic evaluation of 5-(p-tolyl)-1-(quinolin-2-yl)pyrazole-3-carboxylic acid amides with potent antiproliferative activity on human cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.34 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 9.82 |
| CHEMBL3338802 | — | — | 1 | 5.96 |
| CHEMBL3338800 | — | — | 1 | 5.32 |
| CHEMBL3338795 | — | — | 1 | 5.29 |
| CHEMBL3338794 | — | — | 1 | 5.15 |
| CHEMBL3338805 | — | — | 1 | 5.10 |
| CHEMBL3338801 | — | — | 1 | 5.09 |
| CHEMBL3337469 | — | — | 1 | 5.03 |
| CHEMBL3338804 | — | — | 1 | 5.02 |
| CHEMBL3338796 | — | — | 1 | 5.01 |
| CHEMBL3338807 | — | — | 1 | 4.95 |
| CHEMBL3338798 | — | — | 1 | 4.88 |
| CHEMBL3338803 | — | — | 1 | 4.81 |
| CHEMBL3338806 | — | — | 1 | 4.80 |
| CHEMBL3338797 | — | — | 1 | 4.77 |
| CHEMBL3338799 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3338802 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3338800 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3338795 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3338794 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3338805 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3338801 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3337469 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3338804 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3338796 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3338807 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL3338798 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3338803 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL3338806 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL3338797 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3338799 | — | IC50 | = | 39400.0 | nM | 4.41 |