Assay Detail
Binding
CHEMBL3376524
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Inhibition of Pseudomonas aeruginosa pseudolysin using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(Dnp)-OH as substrate after 1 hr by fluorescence assay in presence of Brij-35
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Elastase (CHEMBL1075146) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.79 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3361134 | — | — | 1 | 5.55 |
| CHEMBL234529 | — | — | 1 | 4.48 |
| CHEMBL472899 | — | — | 1 | 4.34 |
| CHEMBL3361129 | — | — | 1 | - |
| CHEMBL3361130 | — | — | 1 | - |
| CHEMBL3361131 | — | — | 1 | - |
| CHEMBL515083 | — | — | 1 | - |
| CHEMBL3361132 | — | — | 1 | - |
| CHEMBL3361133 | — | — | 1 | - |
| CHEMBL234737 | — | — | 1 | - |
| CHEMBL234735 | — | — | 1 | - |
| CHEMBL234530 | — | — | 1 | - |
| CHEMBL515980 | — | — | 1 | - |
| CHEMBL234528 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3361134 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL234529 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL472899 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3361129 | — | IC50 | - | — | - | |
| CHEMBL3361130 | — | IC50 | - | — | - | |
| CHEMBL3361131 | — | IC50 | = | 430000.0 | nM | - |
| CHEMBL515083 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL3361132 | — | IC50 | = | 241000.0 | nM | - |
| CHEMBL3361133 | — | IC50 | - | — | - | |
| CHEMBL234737 | — | IC50 | - | — | - | |
| CHEMBL234735 | — | IC50 | - | — | - | |
| CHEMBL234530 | — | IC50 | = | 276000.0 | nM | - |
| CHEMBL515980 | — | IC50 | = | 336000.0 | nM | - |
| CHEMBL234528 | — | IC50 | - | — | - |