Assay Detail
Binding
CHEMBL3376525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pseudomonas aeruginosa pseudolysin using Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide as substrate after 15 mins
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Elastase (CHEMBL1075146) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.93 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL234737 | — | — | 1 | 6.40 |
| CHEMBL3361134 | — | — | 1 | 5.17 |
| CHEMBL234529 | — | — | 1 | 4.82 |
| CHEMBL234530 | — | — | 1 | 4.80 |
| CHEMBL3361129 | — | — | 1 | 4.70 |
| CHEMBL234735 | — | — | 1 | 4.51 |
| CHEMBL515980 | — | — | 1 | 4.09 |
| CHEMBL3361130 | — | — | 1 | - |
| CHEMBL3361131 | — | — | 1 | - |
| CHEMBL515083 | — | — | 1 | - |
| CHEMBL3361132 | — | — | 1 | - |
| CHEMBL472899 | — | — | 1 | - |
| CHEMBL3361133 | — | — | 1 | - |
| CHEMBL234528 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL234737 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3361134 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL234529 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL234530 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3361129 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL234735 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL515980 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL3361130 | — | IC50 | > | 121000.0 | nM | - |
| CHEMBL3361131 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL515083 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL3361132 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL472899 | — | IC50 | > | 186000.0 | nM | - |
| CHEMBL3361133 | — | IC50 | > | 330000.0 | nM | - |
| CHEMBL234528 | — | IC50 | > | 282000.0 | nM | - |