Assay Detail
Functional
CHEMBL3376629
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Antiprotozoan activity against Giardia lamblia G1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Giardia intestinalis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.26 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.25 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.24 |
| CHEMBL3098602 | — | — | 1 | 5.37 |
| CHEMBL3098604 | — | — | 1 | 5.33 |
| CHEMBL3353926 | — | — | 1 | 5.09 |
| CHEMBL3098691 | — | — | 1 | 4.97 |
| CHEMBL3353925 | — | — | 1 | 4.91 |
| CHEMBL3098695 | — | — | 1 | 4.89 |
| CHEMBL3353928 | — | — | 1 | 4.39 |
| CHEMBL3353927 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3098602 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL3098604 | — | IC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL3353926 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL3098691 | — | IC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL3353925 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL3098695 | — | IC50 | = | 12750.0 | nM | 4.89 |
| CHEMBL3353928 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL3353927 | — | IC50 | = | 64800.0 | nM | 4.19 |