Assay Detail
Functional
CHEMBL3376735
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Antileishmanial activity against Leishmania tropica MHOM/IT/2012/ISS3130 promastigotes assessed as inhibition of parasite growth after 72 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania tropica |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Clofazimine analogs with antileishmanial and antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.02 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.05 |
| CHEMBL3356387 | — | — | 1 | 6.92 |
| CHEMBL3356386 | — | — | 1 | 6.66 |
| CHEMBL3356390 | — | — | 1 | 6.62 |
| CHEMBL3356389 | — | — | 1 | 6.48 |
| CHEMBL3356394 | — | — | 1 | 6.47 |
| CHEMBL3356385 | — | — | 1 | 6.33 |
| CHEMBL3356378 | — | — | 1 | 6.27 |
| CHEMBL3356395 | — | — | 1 | 6.11 |
| CHEMBL3356388 | — | — | 1 | 6.08 |
| CHEMBL3356377 | — | — | 1 | 5.96 |
| CHEMBL3356391 | — | — | 1 | 5.96 |
| CHEMBL3356392 | — | — | 1 | 5.70 |
| CHEMBL3356393 | — | — | 1 | 5.63 |
| CHEMBL3356383 | — | — | 1 | 5.57 |
| CHEMBL1292 | CLOFAZIMINE | 4.0 | 1 | 5.53 |
| CHEMBL3356376 | — | — | 1 | 5.13 |
| CHEMBL3356375 | — | — | 1 | 5.01 |
| CHEMBL3356379 | — | — | 1 | 4.91 |
| CHEMBL3356382 | — | — | 1 | - |
| CHEMBL3356381 | — | — | 1 | - |
| CHEMBL3356380 | — | — | 1 | - |
| CHEMBL3356384 | — | — | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3356387 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3356386 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3356390 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3356389 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3356394 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3356385 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3356378 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3356395 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL3356388 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL3356377 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3356391 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL3356392 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3356393 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL3356383 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1292 | CLOFAZIMINE | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL3356376 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL3356375 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL3356379 | — | IC50 | = | 12280.0 | nM | 4.91 |
| CHEMBL3356382 | — | IC50 | - | — | - | |
| CHEMBL3356381 | — | IC50 | - | — | - | |
| CHEMBL3356380 | — | IC50 | - | — | - | |
| CHEMBL3356384 | — | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | - | — | - |