Assay Detail
Functional
CHEMBL3376834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against bloodstream forms of Trypanosoma brucei brucei Lister 427 after 48 hrs by Alamar blue assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.22 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319009 | — | — | 1 | 6.89 |
| CHEMBL3319008 | — | — | 1 | 6.80 |
| CHEMBL3319007 | — | — | 1 | 6.33 |
| CHEMBL3318495 | — | — | 1 | 6.19 |
| CHEMBL3318926 | — | — | 1 | 5.99 |
| CHEMBL3318490 | — | — | 1 | 5.98 |
| CHEMBL3318925 | — | — | 1 | 5.73 |
| CHEMBL3318924 | — | — | 1 | 5.69 |
| CHEMBL3318211 | — | — | 1 | 5.22 |
| CHEMBL3318489 | — | — | 1 | 5.14 |
| CHEMBL3318494 | — | — | 1 | 5.11 |
| CHEMBL3319010 | — | — | 1 | 5.05 |
| CHEMBL3318491 | — | — | 1 | 4.84 |
| CHEMBL3318802 | — | — | 1 | 4.84 |
| CHEMBL3318497 | — | — | 1 | 4.60 |
| CHEMBL3318803 | — | — | 1 | 4.39 |
| CHEMBL3318498 | — | — | 1 | 4.27 |
| CHEMBL3318210 | — | — | 1 | 4.21 |
| CHEMBL3318212 | — | — | 1 | 4.14 |
| CHEMBL3318487 | — | — | 1 | 4.10 |
| CHEMBL3318804 | — | — | 1 | 4.03 |
| CHEMBL3318801 | — | — | 1 | - |
| CHEMBL567351 | — | — | 1 | - |
| CHEMBL3318496 | — | — | 1 | - |
| CHEMBL3318207 | — | — | 1 | - |
| CHEMBL3318208 | — | — | 1 | - |
| CHEMBL3318209 | — | — | 1 | - |
| CHEMBL3318206 | — | — | 1 | - |
| CHEMBL3318493 | — | — | 1 | - |
| CHEMBL3318213 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319009 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3319008 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3319007 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3318495 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3318926 | — | IC50 | = | 1016.0 | nM | 5.99 |
| CHEMBL3318490 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL3318925 | — | IC50 | = | 1857.0 | nM | 5.73 |
| CHEMBL3318924 | — | IC50 | = | 2038.0 | nM | 5.69 |
| CHEMBL3318211 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL3318489 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3318494 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL3319010 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL3318491 | — | IC50 | = | 14330.0 | nM | 4.84 |
| CHEMBL3318802 | — | IC50 | = | 14470.0 | nM | 4.84 |
| CHEMBL3318497 | — | IC50 | = | 25110.0 | nM | 4.60 |
| CHEMBL3318803 | — | IC50 | = | 41010.0 | nM | 4.39 |
| CHEMBL3318498 | — | IC50 | = | 53340.0 | nM | 4.27 |
| CHEMBL3318210 | — | IC50 | = | 62360.0 | nM | 4.21 |
| CHEMBL3318212 | — | IC50 | = | 72520.0 | nM | 4.14 |
| CHEMBL3318487 | — | IC50 | = | 80060.0 | nM | 4.10 |
| CHEMBL3318804 | — | IC50 | = | 93520.0 | nM | 4.03 |
| CHEMBL3318801 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL567351 | — | IC50 | = | 7620000.0 | nM | - |
| CHEMBL3318496 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL3318207 | — | IC50 | - | — | - | |
| CHEMBL3318208 | — | IC50 | - | — | - | |
| CHEMBL3318209 | — | IC50 | = | 2440000.0 | nM | - |
| CHEMBL3318206 | — | IC50 | - | — | - | |
| CHEMBL3318493 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL3318213 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL3318492 | — | IC50 | = | 340000.0 | nM | - |