Assay Detail
ADMET
CHEMBL3376837
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Cytotoxicity against HEK cells after 16 hrs by resazurin-based fluorescence assay
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 72 | 4.41 | 5.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477683 | PHENYLARSINE OXIDE | — | 1 | 5.83 |
| CHEMBL3318915 | — | — | 1 | 4.73 |
| CHEMBL3318922 | — | — | 1 | 4.58 |
| CHEMBL3319012 | — | — | 1 | 4.49 |
| CHEMBL3319007 | — | — | 1 | 4.49 |
| CHEMBL3318914 | — | — | 1 | 4.49 |
| CHEMBL3318816 | — | — | 1 | 4.48 |
| CHEMBL3319009 | — | — | 1 | 4.46 |
| CHEMBL3318916 | — | — | 1 | 4.46 |
| CHEMBL3318911 | — | — | 1 | 4.41 |
| CHEMBL3319008 | — | — | 1 | 4.41 |
| CHEMBL3318913 | — | — | 1 | 4.40 |
| CHEMBL3318921 | — | — | 1 | 4.34 |
| CHEMBL3318822 | — | — | 1 | 4.33 |
| CHEMBL3318912 | — | — | 1 | 4.33 |
| CHEMBL3318821 | — | — | 1 | 4.31 |
| CHEMBL3318919 | — | — | 1 | 4.27 |
| CHEMBL3318823 | — | — | 1 | 4.27 |
| CHEMBL3318920 | — | — | 1 | 4.24 |
| CHEMBL3318819 | — | — | 1 | 4.24 |
| CHEMBL3318820 | — | — | 1 | 4.20 |
| CHEMBL3318806 | — | — | 1 | 4.15 |
| CHEMBL3318924 | — | — | 1 | 4.13 |
| CHEMBL3318917 | — | — | 1 | 4.11 |
| CHEMBL3318807 | — | — | 1 | 4.09 |
| CHEMBL3318818 | — | — | 1 | - |
| CHEMBL3318817 | — | — | 1 | - |
| CHEMBL3318815 | — | — | 1 | - |
| CHEMBL3318918 | — | — | 1 | - |
| CHEMBL3318813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477683 | PHENYLARSINE OXIDE | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL3318915 | — | IC50 | = | 18460.0 | nM | 4.73 |
| CHEMBL3318922 | — | IC50 | = | 25990.0 | nM | 4.58 |
| CHEMBL3319012 | — | IC50 | = | 32620.0 | nM | 4.49 |
| CHEMBL3319007 | — | IC50 | = | 32450.0 | nM | 4.49 |
| CHEMBL3318914 | — | IC50 | = | 32540.0 | nM | 4.49 |
| CHEMBL3318816 | — | IC50 | = | 33180.0 | nM | 4.48 |
| CHEMBL3319009 | — | IC50 | = | 34980.0 | nM | 4.46 |
| CHEMBL3318916 | — | IC50 | = | 34590.0 | nM | 4.46 |
| CHEMBL3319008 | — | IC50 | = | 39110.0 | nM | 4.41 |
| CHEMBL3318911 | — | IC50 | = | 39140.0 | nM | 4.41 |
| CHEMBL3318913 | — | IC50 | = | 39630.0 | nM | 4.40 |
| CHEMBL3318921 | — | IC50 | = | 45840.0 | nM | 4.34 |
| CHEMBL3318822 | — | IC50 | = | 47340.0 | nM | 4.33 |
| CHEMBL3318912 | — | IC50 | = | 47210.0 | nM | 4.33 |
| CHEMBL3318821 | — | IC50 | = | 49190.0 | nM | 4.31 |
| CHEMBL3318919 | — | IC50 | = | 53340.0 | nM | 4.27 |
| CHEMBL3318823 | — | IC50 | = | 53640.0 | nM | 4.27 |
| CHEMBL3318920 | — | IC50 | = | 57770.0 | nM | 4.24 |
| CHEMBL3318819 | — | IC50 | = | 57700.0 | nM | 4.24 |
| CHEMBL3318820 | — | IC50 | = | 62880.0 | nM | 4.20 |
| CHEMBL3318806 | — | IC50 | = | 70770.0 | nM | 4.15 |
| CHEMBL3318924 | — | IC50 | = | 73360.0 | nM | 4.13 |
| CHEMBL3318917 | — | IC50 | = | 77100.0 | nM | 4.11 |
| CHEMBL3318807 | — | IC50 | = | 81910.0 | nM | 4.09 |
| CHEMBL3318494 | — | IC50 | - | — | - | |
| CHEMBL3318493 | — | IC50 | - | — | - | |
| CHEMBL3318492 | — | IC50 | - | — | - | |
| CHEMBL3318491 | — | IC50 | - | — | - | |
| CHEMBL3318490 | — | IC50 | - | — | - | |
| CHEMBL3318489 | — | IC50 | - | — | - | |
| CHEMBL3318488 | — | IC50 | - | — | - | |
| CHEMBL3318487 | — | IC50 | - | — | - | |
| CHEMBL3318495 | — | IC50 | - | — | - | |
| CHEMBL3318214 | — | IC50 | - | — | - | |
| CHEMBL3318213 | — | IC50 | - | — | - | |
| CHEMBL3318212 | — | IC50 | - | — | - | |
| CHEMBL3318486 | — | IC50 | - | — | - | |
| CHEMBL3319013 | — | IC50 | - | — | - | |
| CHEMBL3319011 | — | IC50 | - | — | - | |
| CHEMBL3319010 | — | IC50 | - | — | - | |
| CHEMBL3318927 | — | IC50 | - | — | - | |
| CHEMBL3318926 | — | IC50 | = | 134200.0 | nM | - |
| CHEMBL3318925 | — | IC50 | = | 149500.0 | nM | - |
| CHEMBL3318923 | — | IC50 | - | — | - | |
| CHEMBL3318813 | — | IC50 | = | 183600.0 | nM | - |
| CHEMBL3318918 | — | IC50 | = | 356400.0 | nM | - |
| CHEMBL3318815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3318817 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL3318818 | — | IC50 | > | 200000.0 | nM | - |