Assay Detail
Functional
CHEMBL3376852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MESSA/DX5 cells assessed as growth inhibition after 72 hrs by CellTitre-Glo assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MES-SA/Dx5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.05 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.59 |
| CHEMBL3318100 | — | — | 1 | 8.34 |
| CHEMBL3318105 | — | — | 1 | 7.80 |
| CHEMBL3318085 | — | — | 1 | 7.12 |
| CHEMBL3318115 | — | — | 1 | 7.06 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.84 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 6.48 |
| CHEMBL3318114 | — | — | 1 | 6.33 |
| CHEMBL3318113 | — | — | 1 | 6.18 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3318100 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3318105 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3318085 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3318115 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL107 | COLCHICINE | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL3318114 | — | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL3318113 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1764.0 | nM | 5.75 |