Assay Detail
Binding
CHEMBL3376860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Uncompetitive inhibition of His-tagged Escherichia coli DXR at 1 to 8 uM pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH and varying DXP substrate level
3
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
1-deoxy-D-xylulose 5-phosphate reductoisomerase (CHEMBL4091) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 1 | - | - |
| Ki | 1 | 5.11 | 5.11 |
| alphaKi | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316879 | — | — | 2 | 5.11 |
| CHEMBL3309763 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316879 | — | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL3309763 | — | Inhibition | - | % | - | |
| CHEMBL2316879 | — | alphaKi | = | 3.0 | uM | - |