Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3376869

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of radioligand from human KISS1R transfected in CHO cells
ChEMBL ↗
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

KiSS-1 receptor (CHEMBL5413) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Physicochemically and pharmacokinetically stable nonapeptide KISS1 receptor agonists with highly potent testosterone-suppressive activity.
Asami T, Nishizawa N, Matsui H, Takatsu Y, Suzuki A, Kiba A, Terada M, Nishibori K, Nakayama M, Ban J, Matsumoto S, Tarui N, Ikeda Y, Yamaguchi M, Kusaka M, Ohtaki T, Kitada C.
J Med Chem (2014) 57 : 6105 -6115
PubMed 24918545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 10.27 10.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3315315 — — 1 10.59
CHEMBL3314227 — — 1 10.57
CHEMBL3314217 — — 1 10.55
CHEMBL3314226 — — 1 10.47
CHEMBL376756 KISSPEPTIN-10 3.0 1 10.46
CHEMBL3314224 — — 1 10.44
CHEMBL3314216 — — 1 10.44
CHEMBL3314215 — — 1 10.43
CHEMBL3314229 — — 1 10.42
CHEMBL3314223 — — 1 10.41
CHEMBL3314209 — — 1 10.28
CHEMBL3314207 — — 1 10.13
CHEMBL3314208 — — 1 10.07
CHEMBL3314228 — — 1 10.05
CHEMBL3314213 — — 1 10.02
CHEMBL3086284 KISS1-305 — 1 9.96
CHEMBL3314222 — — 1 9.92
CHEMBL3314218 — — 1 9.70
CHEMBL3314214 — — 1 -
CHEMBL3314219 — — 1 -
CHEMBL3314220 — — 1 -
CHEMBL3314221 — — 1 -
CHEMBL3314212 — — 1 -
CHEMBL3314225 — — 1 -
CHEMBL3314211 — — 1 -
CHEMBL3314210 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3315315 — Ki = 0.026 nM 10.59
CHEMBL3314227 — Ki = 0.027 nM 10.57
CHEMBL3314217 — Ki = 0.028 nM 10.55
CHEMBL3314226 — Ki = 0.034 nM 10.47
CHEMBL376756 KISSPEPTIN-10 Ki = 0.035 nM 10.46
CHEMBL3314224 — Ki = 0.036 nM 10.44
CHEMBL3314216 — Ki = 0.036 nM 10.44
CHEMBL3314215 — Ki = 0.037 nM 10.43
CHEMBL3314229 — Ki = 0.038 nM 10.42
CHEMBL3314223 — Ki = 0.039 nM 10.41
CHEMBL3314209 — Ki = 0.052 nM 10.28
CHEMBL3314207 — Ki = 0.074 nM 10.13
CHEMBL3314208 — Ki = 0.086 nM 10.07
CHEMBL3314228 — Ki = 0.089 nM 10.05
CHEMBL3314213 — Ki = 0.096 nM 10.02
CHEMBL3086284 KISS1-305 Ki = 0.11 nM 9.96
CHEMBL3314222 — Ki = 0.12 nM 9.92
CHEMBL3314218 — Ki = 0.2 nM 9.70
CHEMBL3314214 — Ki - — -
CHEMBL3314219 — Ki - — -
CHEMBL3314220 — Ki - — -
CHEMBL3314221 — Ki - — -
CHEMBL3314212 — Ki - — -
CHEMBL3314225 — Ki - — -
CHEMBL3314211 — Ki - — -
CHEMBL3314210 — Ki - — -