Assay Detail
Binding
CHEMBL3377010
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Inhibition of human MAGL using 4-Nitrophenylacetate substrate incubated for 15 mins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.07 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2159798 | — | — | 1 | 8.10 |
| CHEMBL2159803 | — | — | 1 | 8.05 |
| CHEMBL2159779 | — | — | 1 | 8.05 |
| CHEMBL3318318 | — | — | 1 | 8.00 |
| CHEMBL2159804 | — | — | 1 | 7.92 |
| CHEMBL570812 | — | — | 1 | 7.70 |
| CHEMBL2159799 | — | — | 1 | 7.48 |
| CHEMBL3318317 | — | — | 1 | 7.41 |
| CHEMBL3318320 | — | — | 1 | 4.00 |
| CHEMBL3318314 | — | — | 1 | 4.00 |
| CHEMBL3318319 | — | — | 1 | - |
| CHEMBL3318316 | — | — | 1 | - |
| CHEMBL1615314 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2159798 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2159803 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2159779 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3318318 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2159804 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL570812 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2159799 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3318317 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3318320 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3318314 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3318319 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3318316 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1615314 | — | IC50 | - | — | - |