Assay Detail
Binding
CHEMBL3377012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to LXRalpha-RXRalpha heterodimer (unknown origin) expressed in insect cells by scintillation proximity assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha (CHEMBL3430879) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.97 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360960 | — | — | 1 | 7.96 |
| CHEMBL3360963 | — | — | 1 | 7.70 |
| CHEMBL3360974 | — | — | 1 | 7.60 |
| CHEMBL3360961 | — | — | 1 | 7.58 |
| CHEMBL62136 | T091317 | — | 1 | 7.51 |
| CHEMBL3360962 | — | — | 1 | 7.44 |
| CHEMBL3360970 | — | — | 1 | 7.21 |
| CHEMBL3360973 | — | — | 1 | 7.18 |
| CHEMBL3360964 | — | — | 1 | 7.17 |
| CHEMBL3360975 | BMS-779788 | 1.0 | 1 | 7.17 |
| CHEMBL3360968 | — | — | 1 | 6.82 |
| CHEMBL3360966 | — | — | 1 | 6.75 |
| CHEMBL3360965 | — | — | 1 | 6.62 |
| CHEMBL3360967 | — | — | 1 | 6.52 |
| CHEMBL3360969 | — | — | 1 | 5.82 |
| CHEMBL3360971 | — | — | 1 | 5.80 |
| CHEMBL3360972 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360960 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3360963 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3360974 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3360961 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL62136 | T091317 | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3360962 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL3360970 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL3360973 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL3360964 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL3360975 | BMS-779788 | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL3360968 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3360966 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3360965 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL3360967 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL3360969 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3360971 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL3360972 | — | Ki | = | 2500.0 | nM | 5.60 |