Assay Detail
Binding
CHEMBL3377019
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Transactivation of LXR in human whole blood assessed as induction of ABCA1 after 4 hrs by SYBR-Green quantitative PCR analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.58 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360966 | — | — | 1 | 9.32 |
| CHEMBL3360975 | BMS-779788 | 1.0 | 1 | 8.92 |
| CHEMBL3360973 | — | — | 1 | 8.51 |
| CHEMBL3360974 | — | — | 1 | 8.49 |
| CHEMBL3360972 | — | — | 1 | 8.15 |
| CHEMBL3360971 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360966 | — | EC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3360975 | BMS-779788 | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3360973 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3360974 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3360972 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3360971 | — | EC50 | = | 8.3 | nM | 8.08 |