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Assay Detail

CHEMBL3377072

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma brucei brucei NYSM bloodstream forms incubated for 46 hrs by alamar blue assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma brucei brucei
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma brucei brucei (CHEMBL612851)
Type ORGANISM
Organism Trypanosoma brucei brucei

Publication

Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica.
Cretton S, Breant L, Pourrez L, Ambuehl C, Marcourt L, Ebrahimi SN, Hamburger M, Perozzo R, Karimou S, Kaiser M, Cuendet M, Christen P.
J Nat Prod (2014) 77 : 2304 -2311
PubMed 25314007 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.93 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL265502 SURAMIN 3.0 1 6.51
CHEMBL3342751 1 4.62
CHEMBL3342750 1 4.51
CHEMBL3342749 1 4.09
CHEMBL3342756 1 -
CHEMBL3342755 1 -
CHEMBL3342754 1 -
CHEMBL3342753 1 -
CHEMBL3341768 1 -
CHEMBL3342752 1 -
CHEMBL3342748 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL265502 SURAMIN IC50 = 310.0 nM 6.51
CHEMBL3342751 IC50 = 24100.0 nM 4.62
CHEMBL3342750 IC50 = 31000.0 nM 4.51
CHEMBL3342749 IC50 = 80300.0 nM 4.09
CHEMBL3342756 IC50 > 100000.0 nM -
CHEMBL3342755 IC50 - -
CHEMBL3342754 IC50 > 100000.0 nM -
CHEMBL3342753 IC50 > 100000.0 nM -
CHEMBL3341768 IC50 > 100000.0 nM -
CHEMBL3342752 IC50 - -
CHEMBL3342748 IC50 > 100000.0 nM -