Assay Detail
ADMET
CHEMBL3377075
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Cytotoxicity against rat L6 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Cell Type | L6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.02 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.70 |
| CHEMBL3342754 | — | — | 1 | 7.16 |
| CHEMBL3341768 | — | — | 1 | 6.72 |
| CHEMBL3342752 | — | — | 1 | 6.58 |
| CHEMBL3342751 | — | — | 1 | 6.19 |
| CHEMBL3342748 | — | — | 1 | 6.12 |
| CHEMBL3342749 | — | — | 1 | 6.04 |
| CHEMBL3342753 | — | — | 1 | 4.66 |
| CHEMBL3342750 | — | — | 1 | 4.59 |
| CHEMBL3342755 | — | — | 1 | 4.39 |
| CHEMBL3342756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3342754 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3341768 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3342752 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3342751 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3342748 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3342749 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL3342753 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL3342750 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL3342755 | — | IC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL3342756 | — | IC50 | = | 184300.0 | nM | - |