Assay Detail
Binding
CHEMBL3377084
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 5B at pH7 and 37 degC by fluorescent thermal shift assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Carbonic anhydrase 5B, mitochondrial (CHEMBL3969) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.60 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333416 | — | — | 1 | 8.89 |
| CHEMBL3359181 | — | — | 1 | 8.25 |
| CHEMBL2333417 | — | — | 1 | 7.66 |
| CHEMBL3359179 | — | — | 1 | 6.68 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.51 |
| CHEMBL3359180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333416 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL3359181 | — | Kd | = | 5.6 | nM | 8.25 |
| CHEMBL2333417 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL3359179 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 310.0 | nM | 6.51 |
| CHEMBL3359180 | — | Kd | > | 200000.0 | nM | - |