Assay Detail
Functional
CHEMBL3377407
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Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by MTT method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.27 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318105 | — | — | 1 | 8.41 |
| CHEMBL3318100 | — | — | 1 | 8.01 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318105 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3318100 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3990.0 | nM | 5.40 |