Assay Detail

CHEMBL3377427

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Functional

Inhibition of hedgehog signaling in mouse NIH/3T3 Shh-Light II cells after 48 hrs by luciferase reporter gene assay

ChEMBL ↗

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Target

Molecular identity unknown (CHEMBL612546) ↗

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Molecular identity unknown (CHEMBL612546) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Molecular identity unknown

CHEMBL612546

Anchored from Assay target.

Protein identity Molecular identity unknown

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Cell Type	Shh Light II
Confidence	3 — Cell-line / Tissue
Curated By	Autocuration

Target

Molecular identity unknown (CHEMBL612546) ↗

Type

UNKNOWN

Publication

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.
J Med Chem (2014) 57 : 6531 -6552
PubMed 25025991 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Inhibition	2	-	-
IC50	2	6.17	6.17

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3318100	—	—	2	6.17
CHEMBL3318105	—	—	2	6.17

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3318100	—	IC50	=	676.0	nM	6.17
CHEMBL3318105	—	IC50	=	682.0	nM	6.17
CHEMBL3318100	—	Inhibition		-	%	-
CHEMBL3318105	—	Inhibition		-	%	-