Assay Detail
Binding
CHEMBL3377637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant caspase 1 using Ac-YVAD-AMC substrate assessed as accumulation of cleaved fluorogenic product
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.24 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359200 | — | — | 1 | 5.59 |
| CHEMBL3359203 | — | — | 1 | 5.13 |
| CHEMBL3359202 | — | — | 1 | 5.00 |
| CHEMBL3359201 | — | — | 1 | - |
| CHEMBL3359199 | — | — | 1 | - |
| CHEMBL3359198 | — | — | 1 | - |
| CHEMBL3359197 | — | — | 1 | - |
| CHEMBL3359196 | — | — | 1 | - |
| CHEMBL3359195 | — | — | 1 | - |
| CHEMBL3359194 | — | — | 1 | - |
| CHEMBL3359193 | — | — | 1 | - |
| CHEMBL3359192 | — | — | 1 | - |
| CHEMBL3359191 | — | — | 1 | - |
| CHEMBL3359190 | — | — | 1 | - |
| CHEMBL3359189 | — | — | 1 | - |
| CHEMBL3359188 | — | — | 1 | - |
| CHEMBL3359187 | — | — | 1 | - |
| CHEMBL3359186 | — | — | 1 | - |
| CHEMBL3359185 | — | — | 1 | - |
| CHEMBL3359184 | — | — | 1 | - |
| CHEMBL3359183 | — | — | 1 | - |
| CHEMBL3359182 | — | — | 1 | - |
| CHEMBL494140 | — | — | 1 | - |
| CHEMBL521840 | — | — | 1 | - |
| CHEMBL493926 | — | — | 1 | - |
| CHEMBL521839 | — | — | 1 | - |
| CHEMBL216819 | — | — | 1 | - |
| CHEMBL60190 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359200 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL3359203 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL3359202 | — | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL3359201 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359199 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359198 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359197 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359196 | — | IC50 | - | — | - | |
| CHEMBL3359195 | — | IC50 | - | — | - | |
| CHEMBL3359194 | — | IC50 | - | — | - | |
| CHEMBL3359193 | — | IC50 | - | — | - | |
| CHEMBL3359192 | — | IC50 | - | — | - | |
| CHEMBL3359191 | — | IC50 | - | — | - | |
| CHEMBL3359190 | — | IC50 | - | — | - | |
| CHEMBL3359189 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359188 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359187 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359186 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL3359185 | — | IC50 | - | — | - | |
| CHEMBL3359184 | — | IC50 | - | — | - | |
| CHEMBL3359183 | — | IC50 | - | — | - | |
| CHEMBL3359182 | — | IC50 | - | — | - | |
| CHEMBL494140 | — | IC50 | - | — | - | |
| CHEMBL521840 | — | IC50 | - | — | - | |
| CHEMBL493926 | — | IC50 | - | — | - | |
| CHEMBL521839 | — | IC50 | - | — | - | |
| CHEMBL216819 | — | IC50 | - | — | - | |
| CHEMBL60190 | — | IC50 | = | 500000.0 | nM | - |