Assay Detail
Functional
CHEMBL3378161
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Cytotoxicity against human HL60 cells by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic activity of substituted chalcones in terms of molecular electronic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.84 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255773 | — | — | 1 | 5.28 |
| CHEMBL388217 | — | — | 1 | 5.24 |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | — | 1 | 5.20 |
| CHEMBL126804 | — | — | 1 | 5.15 |
| CHEMBL89988 | — | — | 1 | 5.14 |
| CHEMBL2375421 | — | — | 1 | 5.11 |
| CHEMBL241861 | — | — | 1 | 5.08 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | — | 1 | 4.75 |
| CHEMBL453987 | CHROMANONE | — | 1 | 4.72 |
| CHEMBL521653 | — | — | 1 | 4.41 |
| CHEMBL241862 | — | — | 1 | 4.31 |
| CHEMBL274318 | FLAVANONE | — | 1 | 4.29 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255773 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL388217 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL126804 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL89988 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2375421 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL241861 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL453987 | CHROMANONE | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL521653 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL241862 | — | IC50 | = | 48700.0 | nM | 4.31 |
| CHEMBL274318 | FLAVANONE | IC50 | = | 51100.0 | nM | 4.29 |
| CHEMBL7976 | CHALCONE | IC50 | = | 55400.0 | nM | 4.26 |