Assay Detail
Functional
CHEMBL3378375
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Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Semisynthesis of triptolide analogues: effect of B-ring substituents on cytotoxic activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.37 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 7.70 |
| CHEMBL205190 | TRIPTONIDE | — | 1 | 7.58 |
| CHEMBL3358845 | — | — | 1 | 7.07 |
| CHEMBL3358846 | — | — | 1 | 6.98 |
| CHEMBL3358850 | — | — | 1 | 6.90 |
| CHEMBL3358849 | — | — | 1 | 6.77 |
| CHEMBL3358844 | — | — | 1 | 6.65 |
| CHEMBL3358841 | — | — | 1 | 6.56 |
| CHEMBL3358842 | — | — | 1 | 6.48 |
| CHEMBL3358843 | — | — | 1 | 6.42 |
| CHEMBL3358855 | — | — | 1 | 6.23 |
| CHEMBL562667 | — | — | 1 | 6.20 |
| CHEMBL3358847 | — | — | 1 | 6.06 |
| CHEMBL3358848 | — | — | 1 | 6.05 |
| CHEMBL3358854 | — | — | 1 | 5.64 |
| CHEMBL561903 | — | — | 1 | 5.58 |
| CHEMBL3358851 | — | — | 1 | 5.49 |
| CHEMBL3358852 | — | — | 1 | 5.39 |
| CHEMBL3358853 | — | — | 1 | 5.30 |
| CHEMBL3358856 | — | — | 1 | - |
| CHEMBL3358857 | — | — | 1 | - |
| CHEMBL3358858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL205190 | TRIPTONIDE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3358845 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3358846 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL3358850 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3358849 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL3358844 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL3358841 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL3358842 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL3358843 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL3358855 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL562667 | — | IC50 | = | 637.0 | nM | 6.20 |
| CHEMBL3358847 | — | IC50 | = | 871.0 | nM | 6.06 |
| CHEMBL3358848 | — | IC50 | = | 893.0 | nM | 6.05 |
| CHEMBL3358854 | — | IC50 | = | 2272.0 | nM | 5.64 |
| CHEMBL561903 | — | IC50 | = | 2613.0 | nM | 5.58 |
| CHEMBL3358851 | — | IC50 | = | 3224.0 | nM | 5.49 |
| CHEMBL3358852 | — | IC50 | = | 4052.0 | nM | 5.39 |
| CHEMBL3358853 | — | IC50 | = | 5043.0 | nM | 5.30 |
| CHEMBL3358856 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358857 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3358858 | — | IC50 | > | 10000.0 | nM | - |