Assay Detail
Functional
CHEMBL3378701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against CLL5 cells isolated from CLL patient assessed as cell viability after 48 hrs by FACS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.84 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 6.80 |
| CHEMBL1096256 | AGELASTATIN A | — | 1 | 6.54 |
| CHEMBL3133723 | — | — | 1 | 6.47 |
| CHEMBL3298665 | — | — | 1 | 5.70 |
| CHEMBL3298667 | — | — | 1 | 5.51 |
| CHEMBL3298662 | — | — | 1 | 5.32 |
| CHEMBL3298670 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1568 | FLUDARABINE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1096256 | AGELASTATIN A | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3133723 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3298665 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL3298667 | — | EC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL3298662 | — | EC50 | = | 4790.0 | nM | 5.32 |
| CHEMBL3298670 | — | EC50 | = | 28400.0 | nM | 4.55 |