Assay Detail
Binding
CHEMBL3378756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MRP1 (unknown origin) expressed in MDCK cells after 30 mins by Calcein-AM assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.07 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3317931 | — | — | 1 | 5.66 |
| CHEMBL3317923 | — | — | 1 | 5.47 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.46 |
| CHEMBL3317922 | — | — | 1 | 5.37 |
| CHEMBL3317918 | — | — | 1 | 5.24 |
| CHEMBL3317921 | — | — | 1 | 5.20 |
| CHEMBL3317937 | — | — | 1 | 5.09 |
| CHEMBL3317936 | — | — | 1 | 4.96 |
| CHEMBL3317920 | — | — | 1 | 4.87 |
| CHEMBL3317935 | — | — | 1 | 4.80 |
| CHEMBL3317938 | — | — | 1 | 4.63 |
| CHEMBL3317934 | — | — | 1 | 4.03 |
| CHEMBL3317929 | — | — | 1 | - |
| CHEMBL3317933 | — | — | 1 | - |
| CHEMBL3317932 | — | — | 1 | - |
| CHEMBL3317930 | — | — | 1 | - |
| CHEMBL3317928 | — | — | 1 | - |
| CHEMBL3317927 | — | — | 1 | - |
| CHEMBL3317926 | — | — | 1 | - |
| CHEMBL3317925 | — | — | 1 | - |
| CHEMBL3317924 | — | — | 1 | - |
| CHEMBL3317919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3317931 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3317923 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3317922 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL3317918 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3317921 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL3317937 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL3317936 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL3317920 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL3317935 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3317938 | — | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL3317934 | — | IC50 | = | 94500.0 | nM | 4.03 |
| CHEMBL3317929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317933 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317932 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317930 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317928 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317926 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317925 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317924 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3317919 | — | IC50 | > | 100000.0 | nM | - |