Assay Detail
Binding
CHEMBL3378763
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Inhibition of influenza A virus (A/California/07/2009(H1N1)) pdm09 neuraminidase using MUNANA substrate pre-incubated for 30 mins before substrate addition by fluorometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/07/2009(H1N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL3559643) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/USSR/90/1977 H1N1) |
Publication
Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.01 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 8.59 |
| CHEMBL251254 | HYPEROSIDE | — | 1 | 4.20 |
| CHEMBL233929 | GALUTEOLIN | — | 1 | 4.18 |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 4.07 |
| CHEMBL226335 | RUTIN | 3.0 | 1 | 4.01 |
| CHEMBL250450 | ISOQUERCETIN | 2.0 | 1 | - |
| CHEMBL82242 | QUERCITRIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229 | OSELTAMIVIR | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL251254 | HYPEROSIDE | IC50 | = | 62500.0 | nM | 4.20 |
| CHEMBL233929 | GALUTEOLIN | IC50 | = | 66600.0 | nM | 4.18 |
| CHEMBL150 | KAEMPFEROL | IC50 | = | 85200.0 | nM | 4.07 |
| CHEMBL226335 | RUTIN | IC50 | = | 96800.0 | nM | 4.01 |
| CHEMBL250450 | ISOQUERCETIN | IC50 | = | 370200.0 | nM | - |
| CHEMBL82242 | QUERCITRIN | IC50 | = | 109000.0 | nM | - |