Assay Detail
Binding
CHEMBL3378876
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cystic fibrosis transmembrane conductance regulator (CHEMBL4051) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery heralds new approach to the treatment of cystic fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.07 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2010601 | IVACAFTOR | 4.0 | 1 | 8.52 |
| CHEMBL3354673 | — | — | 1 | 7.00 |
| CHEMBL3354672 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2010601 | IVACAFTOR | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3354673 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3354672 | — | EC50 | = | 2100.0 | nM | 5.68 |