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Assay Detail

CHEMBL3379268

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LPS-induced IL-1beta production in mouse RAW264.7 cells after 24 hrs by ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Autocuration

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

2-Phenoxychromones and prenylflavonoids from Epimedium koreanum and their inhibitory effects on LPS-induced nitric oxide and interleukin-1β production.
Jin Q, Lee C, Lee JW, Yeon ET, Lee D, Han SB, Hong JT, Kim Y, Lee MK, Hwang BY.
J Nat Prod (2014) 77 : 1724 -1728
PubMed 24963714 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.76 5.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3314708 1 5.07
CHEMBL3314706 1 5.06
CHEMBL6 INDOMETHACIN 4.0 1 4.73
CHEMBL3314705 1 4.54
CHEMBL180920 MAGNOLOL 1 4.41
CHEMBL3314714 1 -
CHEMBL3314713 1 -
CHEMBL2392402 (+)-EPILOLIOLIDE 1 -
CHEMBL227113 LOLIOLIDE 1 -
CHEMBL3314712 1 -
CHEMBL3314711 1 -
CHEMBL3314710 1 -
CHEMBL3314709 1 -
CHEMBL225304 PIMAGEDINE 2.0 1 -
CHEMBL487611 PINORESINOL 1 -
CHEMBL3314707 1 -
CHEMBL461278 1 -
CHEMBL402653 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3314708 IC50 = 8600.0 nM 5.07
CHEMBL3314706 IC50 = 8800.0 nM 5.06
CHEMBL6 INDOMETHACIN IC50 = 18700.0 nM 4.73
CHEMBL3314705 IC50 = 28900.0 nM 4.54
CHEMBL180920 MAGNOLOL IC50 = 38900.0 nM 4.41
CHEMBL3314714 IC50 > 50000.0 nM -
CHEMBL3314713 IC50 > 50000.0 nM -
CHEMBL2392402 (+)-EPILOLIOLIDE IC50 > 50000.0 nM -
CHEMBL227113 LOLIOLIDE IC50 > 50000.0 nM -
CHEMBL3314712 IC50 > 50000.0 nM -
CHEMBL3314711 IC50 > 50000.0 nM -
CHEMBL3314710 IC50 > 50000.0 nM -
CHEMBL3314709 IC50 > 50000.0 nM -
CHEMBL225304 PIMAGEDINE IC50 - -
CHEMBL487611 PINORESINOL IC50 > 50000.0 nM -
CHEMBL3314707 IC50 > 50000.0 nM -
CHEMBL461278 IC50 > 50000.0 nM -
CHEMBL402653 IC50 > 50000.0 nM -