Assay Detail
Binding
CHEMBL3379280
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat shock protein HSP 90 (CHEMBL1667702) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.82 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.55 |
| CHEMBL3360777 | — | — | 1 | 5.39 |
| CHEMBL3360776 | — | — | 1 | 5.07 |
| CHEMBL3360770 | — | — | 1 | 4.84 |
| CHEMBL389471 | COUMERMYCIN A1 | — | 1 | 4.55 |
| CHEMBL3360775 | — | — | 1 | 4.50 |
| CHEMBL3360773 | — | — | 1 | 4.43 |
| CHEMBL3360769 | — | — | 1 | 4.42 |
| CHEMBL3360774 | — | — | 1 | 4.42 |
| CHEMBL3360767 | — | — | 1 | 4.03 |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 1 | - |
| CHEMBL3360762 | — | — | 1 | - |
| CHEMBL3360771 | — | — | 1 | - |
| CHEMBL3360772 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL3360777 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL3360776 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL3360770 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL389471 | COUMERMYCIN A1 | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL3360775 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL3360773 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL3360769 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL3360774 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL3360767 | — | IC50 | = | 94500.0 | nM | 4.03 |
| CHEMBL36506 | NOVOBIOCIN | IC50 | = | 414000.0 | nM | - |
| CHEMBL3360762 | — | IC50 | = | 233000.0 | nM | - |
| CHEMBL3360771 | — | IC50 | = | 168000.0 | nM | - |
| CHEMBL3360772 | — | IC50 | = | 137000.0 | nM | - |