Assay Detail
Functional
CHEMBL3379492
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Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353926 | — | — | 1 | 7.12 |
| CHEMBL3356948 | — | — | 1 | 7.07 |
| CHEMBL3356940 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353926 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3356948 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3356940 | — | IC50 | = | 130.0 | nM | 6.89 |