Assay Detail
Binding
CHEMBL3379812
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Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex by Lineweaver-Burk plot
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.95 | 7.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322160 | — | — | 1 | 7.63 |
| CHEMBL3322141 | — | — | 1 | 7.10 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.00 |
| CHEMBL3322142 | — | — | 1 | 6.48 |
| CHEMBL1256415 | — | — | 1 | 5.20 |
| CHEMBL3322162 | — | — | 1 | 4.18 |
| CHEMBL3322161 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322160 | — | Ki | = | 23.4 | nM | 7.63 |
| CHEMBL3322141 | — | Ki | = | 78.9 | nM | 7.10 |
| CHEMBL95 | TACRINE | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL3322142 | — | Ki | = | 328.0 | nM | 6.48 |
| CHEMBL1256415 | — | Ki | = | 6340.0 | nM | 5.20 |
| CHEMBL3322162 | — | Ki | = | 65300.0 | nM | 4.18 |
| CHEMBL3322161 | — | Ki | = | 92800.0 | nM | 4.03 |