Assay Detail
Functional
CHEMBL3379944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.21 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1221681 | — | — | 1 | 9.60 |
| CHEMBL1095777 | INDACATEROL | 4.0 | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1221681 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL1095777 | INDACATEROL | EC50 | = | 1.5 | nM | 8.82 |