Assay Detail
Binding
CHEMBL3380146
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Agonist activity at human S1P5 receptor by beta-arrestin recruitment assay
8
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.75 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359523 | — | — | 1 | 7.72 |
| CHEMBL3359522 | — | — | 1 | 7.33 |
| CHEMBL3358955 | — | — | 2 | 7.09 |
| CHEMBL3359520 | — | — | 2 | 6.39 |
| CHEMBL3359519 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359523 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3359522 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3358955 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3358955 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3359520 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3359520 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3359519 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3359519 | — | EC50 | > | 10000.0 | nM | - |