Assay Detail
Functional
CHEMBL3380231
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Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel substituted purine derivatives and identification of the cell death mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.96 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | 4.0 | 1 | 6.52 |
| CHEMBL3355813 | — | — | 1 | 5.35 |
| CHEMBL3355391 | — | — | 1 | 5.29 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.22 |
| CHEMBL1568 | FLUDARABINE | 3.0 | 1 | 5.18 |
| CHEMBL3355819 | — | — | 1 | 5.06 |
| CHEMBL507307 | — | — | 1 | 4.89 |
| CHEMBL3355814 | — | — | 1 | 4.84 |
| CHEMBL503112 | — | — | 1 | 4.78 |
| CHEMBL3355389 | — | — | 1 | 4.64 |
| CHEMBL3355818 | — | — | 1 | 4.55 |
| CHEMBL3355824 | — | — | 1 | 4.14 |
| CHEMBL1864461 | — | — | 1 | 4.06 |
| CHEMBL3355820 | — | — | 1 | - |
| CHEMBL447034 | — | — | 1 | - |
| CHEMBL3355393 | — | — | 1 | - |
| CHEMBL3355821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1619 | CLADRIBINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3355813 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3355391 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1568 | FLUDARABINE | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3355819 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL507307 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3355814 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL503112 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL3355389 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3355818 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL3355824 | — | IC50 | = | 72400.0 | nM | 4.14 |
| CHEMBL1864461 | — | IC50 | = | 86600.0 | nM | 4.06 |
| CHEMBL3355820 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL447034 | — | IC50 | = | 131600.0 | nM | - |
| CHEMBL3355393 | — | IC50 | = | 102100.0 | nM | - |
| CHEMBL3355821 | — | IC50 | > | 200000.0 | nM | - |