Assay Detail
Functional
CHEMBL3380326
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Antiproliferative activity against human HCT116 cells after 72 hrs by ATPlite assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.80 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3356795 | — | — | 1 | 9.52 |
| CHEMBL198075 | CRYPTOPLEURINE | — | 1 | 9.15 |
| CHEMBL3356793 | — | — | 1 | 8.85 |
| CHEMBL3356794 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3356795 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL198075 | CRYPTOPLEURINE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3356793 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3356794 | — | IC50 | = | 21.0 | nM | 7.68 |