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Assay Detail

CHEMBL3380388

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Functional
Antiproliferative activity against human Molt4/C8 cells after 72 hrs by coulter counting analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MOLT-4
Confidence 1 — Organism
Curated By Autocuration

Publication

Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.
Santiago-Vazquez Y, Das S, Das U, Robles-Escajeda E, Ortega NM, Lema C, Varela-Ramírez A, Aguilera RJ, Balzarini J, De Clercq E, Dimmock SG, Gorecki DK, Dimmock JR.
Eur J Med Chem (2014) 77 : 315 -322
PubMed 24657568 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.01 7.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3313947 1 7.33
CHEMBL2391219 1 7.22
CHEMBL2391212 1 7.14
CHEMBL2391207 1 7.08
CHEMBL2391205 1 6.53
CHEMBL2391218 1 6.41
CHEMBL2012925 1 6.33
CHEMBL2391209 1 6.11
CHEMBL2391214 1 5.98
CHEMBL2391222 1 5.84
CHEMBL2391216 1 5.80
CHEMBL2391204 1 5.78
CHEMBL2391213 1 5.72
CHEMBL852 MELPHALAN 4.0 1 5.55
CHEMBL140 CURCUMIN 3.0 1 5.19
CHEMBL2391206 1 5.07
CHEMBL2391215 1 4.63
CHEMBL2391208 1 4.48
CHEMBL2391211 1 -
CHEMBL2391217 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3313947 IC50 = 47.0 nM 7.33
CHEMBL2391219 IC50 = 60.0 nM 7.22
CHEMBL2391212 IC50 = 73.0 nM 7.14
CHEMBL2391207 IC50 = 83.0 nM 7.08
CHEMBL2391205 IC50 = 294.0 nM 6.53
CHEMBL2391218 IC50 = 388.0 nM 6.41
CHEMBL2012925 IC50 = 462.0 nM 6.33
CHEMBL2391209 IC50 = 779.0 nM 6.11
CHEMBL2391214 IC50 = 1050.0 nM 5.98
CHEMBL2391222 IC50 = 1450.0 nM 5.84
CHEMBL2391216 IC50 = 1580.0 nM 5.80
CHEMBL2391204 IC50 = 1660.0 nM 5.78
CHEMBL2391213 IC50 = 1890.0 nM 5.72
CHEMBL852 MELPHALAN IC50 = 2810.0 nM 5.55
CHEMBL140 CURCUMIN IC50 = 6460.0 nM 5.19
CHEMBL2391206 IC50 = 8460.0 nM 5.07
CHEMBL2391215 IC50 = 23500.0 nM 4.63
CHEMBL2391208 IC50 = 33100.0 nM 4.48
CHEMBL2391211 IC50 = 437000.0 nM -
CHEMBL2391217 IC50 = 449000.0 nM -