Assay Detail
Functional
CHEMBL3380401
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Antileukemic activity against human SR cells assessed as inhibition of tumor growth after 24 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.92 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2391214 | — | — | 1 | 8.00 |
| CHEMBL2391219 | — | — | 1 | 8.00 |
| CHEMBL2012925 | — | — | 1 | 7.70 |
| CHEMBL2391205 | — | — | 1 | 7.70 |
| CHEMBL3313947 | — | — | 1 | 7.70 |
| CHEMBL2391212 | — | — | 1 | 7.52 |
| CHEMBL2391222 | — | — | 1 | 7.40 |
| CHEMBL2391213 | — | — | 1 | 7.30 |
| CHEMBL2391207 | — | — | 1 | 6.80 |
| CHEMBL2391221 | — | — | 1 | 6.34 |
| CHEMBL2391206 | — | — | 1 | 5.75 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.49 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2391214 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2391219 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012925 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2391205 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3313947 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2391212 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2391222 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2391213 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2391207 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2391221 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2391206 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL852 | MELPHALAN | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 60300.0 | nM | 4.22 |