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Assay Detail

CHEMBL3380438

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Functional
Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.
Jagtap AD, Chang PT, Liu JR, Wang HC, Kondekar NB, Shen LJ, Tseng HW, Chen GS, Chern JW.
Eur J Med Chem (2014) 85 : 268 -288
PubMed 25089810 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 7.38 8.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3329685 — — 1 8.55
CHEMBL3329684 — — 1 8.55
CHEMBL3329672 — — 1 8.19
CHEMBL3329669 — — 1 8.19
CHEMBL3329668 — — 1 8.09
CHEMBL3329675 — — 1 8.05
CHEMBL215152 DEFOSBARASERTIB 2.0 1 7.90
CHEMBL3329676 — — 1 7.89
CHEMBL3329682 — — 1 7.85
CHEMBL3329679 — — 1 7.80
CHEMBL3329678 — — 1 7.80
CHEMBL3329664 — — 1 7.80
CHEMBL3329673 — — 1 7.78
CHEMBL3329683 — — 1 7.69
CHEMBL3329656 — — 1 7.67
CHEMBL3329660 — — 1 7.63
CHEMBL3329680 — — 1 7.62
CHEMBL3329671 — — 1 7.54
CHEMBL3329674 — — 1 7.54
CHEMBL3329652 — — 1 7.53
CHEMBL3329677 — — 1 7.52
CHEMBL3329681 — — 1 7.51
CHEMBL3329670 — — 1 7.49
CHEMBL3329657 — — 1 7.46
CHEMBL535 SUNITINIB 4.0 1 7.43
CHEMBL3329665 — — 1 7.34
CHEMBL3330971 — — 1 7.30
CHEMBL3329655 — — 1 6.60
CHEMBL3329662 — — 1 6.60
CHEMBL3329663 — — 1 6.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3329685 — IC50 = 2.8 nM 8.55
CHEMBL3329684 — IC50 = 2.8 nM 8.55
CHEMBL3329669 — IC50 = 6.4 nM 8.19
CHEMBL3329672 — IC50 = 6.4 nM 8.19
CHEMBL3329668 — IC50 = 8.1 nM 8.09
CHEMBL3329675 — IC50 = 8.9 nM 8.05
CHEMBL215152 DEFOSBARASERTIB IC50 = 12.7 nM 7.90
CHEMBL3329676 — IC50 = 13.0 nM 7.89
CHEMBL3329682 — IC50 = 14.1 nM 7.85
CHEMBL3329679 — IC50 = 15.7 nM 7.80
CHEMBL3329678 — IC50 = 15.7 nM 7.80
CHEMBL3329664 — IC50 = 15.8 nM 7.80
CHEMBL3329673 — IC50 = 16.7 nM 7.78
CHEMBL3329683 — IC50 = 20.3 nM 7.69
CHEMBL3329656 — IC50 = 21.6 nM 7.67
CHEMBL3329660 — IC50 = 23.2 nM 7.63
CHEMBL3329680 — IC50 = 24.0 nM 7.62
CHEMBL3329671 — IC50 = 28.8 nM 7.54
CHEMBL3329674 — IC50 = 28.6 nM 7.54
CHEMBL3329652 — IC50 = 29.5 nM 7.53
CHEMBL3329677 — IC50 = 29.9 nM 7.52
CHEMBL3329681 — IC50 = 31.2 nM 7.51
CHEMBL3329670 — IC50 = 32.2 nM 7.49
CHEMBL3329657 — IC50 = 35.0 nM 7.46
CHEMBL535 SUNITINIB IC50 = 36.8 nM 7.43
CHEMBL3329665 — IC50 = 45.8 nM 7.34
CHEMBL3330971 — IC50 = 50.4 nM 7.30
CHEMBL3329655 — IC50 = 249.9 nM 6.60
CHEMBL3329662 — IC50 = 250.9 nM 6.60
CHEMBL3329663 — IC50 = 269.3 nM 6.57
CHEMBL3329658 — IC50 = 268.0 nM 6.57
CHEMBL3329659 — IC50 = 292.6 nM 6.53
CHEMBL3361346 — IC50 = 300.2 nM 6.52
CHEMBL3329651 — IC50 = 300.7 nM 6.52
CHEMBL3329661 — IC50 = 301.2 nM 6.52
CHEMBL3329650 — IC50 = 334.5 nM 6.48
CHEMBL3330970 — IC50 = 336.0 nM 6.47
CHEMBL3330969 — IC50 = 484.8 nM 6.31
CHEMBL3329653 — IC50 = 488.0 nM 6.31
CHEMBL3329667 — IC50 > 500.0 nM -
CHEMBL3329666 — IC50 > 500.0 nM -
CHEMBL3329686 — IC50 > 500.0 nM -
CHEMBL3329687 — IC50 > 500.0 nM -
CHEMBL3330968 — IC50 > 500.0 nM -
CHEMBL3330972 — IC50 > 500.0 nM -
CHEMBL3361347 — IC50 > 500.0 nM -
CHEMBL3330975 — IC50 > 500.0 nM -
CHEMBL3330976 — IC50 > 500.0 nM -