Assay Detail
Binding
CHEMBL3380855
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Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by modified Ellman's method
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.64 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359473 | — | — | 1 | 6.40 |
| CHEMBL3359481 | — | — | 1 | 6.12 |
| CHEMBL3359485 | — | — | 1 | 6.12 |
| CHEMBL3359496 | — | — | 1 | 6.05 |
| CHEMBL3359472 | — | — | 1 | 6.05 |
| CHEMBL3359478 | — | — | 1 | 6.00 |
| CHEMBL3359492 | — | — | 1 | 5.99 |
| CHEMBL3359489 | — | — | 1 | 5.98 |
| CHEMBL3359474 | — | — | 1 | 5.95 |
| CHEMBL3359471 | — | — | 1 | 5.94 |
| CHEMBL3359495 | — | — | 1 | 5.90 |
| CHEMBL3359480 | — | — | 1 | 5.83 |
| CHEMBL3359494 | — | — | 1 | 5.82 |
| CHEMBL3359484 | — | — | 1 | 5.81 |
| CHEMBL3359476 | — | — | 1 | 5.79 |
| CHEMBL3359479 | — | — | 1 | 5.79 |
| CHEMBL3359490 | — | — | 1 | 5.78 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.68 |
| CHEMBL3359477 | — | — | 1 | 5.62 |
| CHEMBL3359470 | — | — | 1 | 5.60 |
| CHEMBL3359475 | — | — | 1 | 5.54 |
| CHEMBL3359488 | — | — | 1 | 5.48 |
| CHEMBL3359487 | — | — | 1 | 5.38 |
| CHEMBL3359493 | — | — | 1 | 5.33 |
| CHEMBL3359482 | — | — | 1 | 5.32 |
| CHEMBL3359491 | — | — | 1 | 5.32 |
| CHEMBL3359486 | — | — | 1 | 5.23 |
| CHEMBL3359467 | — | — | 1 | 4.95 |
| CHEMBL3359466 | — | — | 1 | 4.87 |
| CHEMBL3359483 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359473 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3359481 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3359485 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3359496 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3359472 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3359478 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3359492 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL3359489 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3359474 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3359471 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL3359495 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3359480 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL3359494 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3359484 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL3359479 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3359476 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL3359490 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL3359477 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL3359470 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL3359475 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL3359488 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL3359487 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3359493 | — | IC50 | = | 4630.0 | nM | 5.33 |
| CHEMBL3359482 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL3359491 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL3359486 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL3359467 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL3359466 | — | IC50 | = | 13530.0 | nM | 4.87 |
| CHEMBL3359483 | — | IC50 | = | 13680.0 | nM | 4.86 |
| CHEMBL3359468 | — | IC50 | = | 35520.0 | nM | 4.45 |
| CHEMBL490355 | SULFURETIN | IC50 | = | 698880.0 | nM | - |
| CHEMBL3359469 | — | IC50 | = | 185650.0 | nM | - |